After some development work today I found a really useful way to check Chrome with all Security Restrictions turned off. Of course this should never be used as a production browser and only on sites you explicitly trust.

On Windows:
Enter the following in the run box or start menu:

C:\Program Files\Google\Chrome\Application\chrome.exe --args --disable-web-security

On Mac Run the following from the Terminal:

open -a "Google" --args --disable-web-security